Dawb T4 - tus qauv hauv poj niam cov ntshav

2024 Tus sau: James Gerald | [email protected]. Kawg hloov kho: 2024-01-12 17:42

Daim ntawv dawb thyroxine (tetraiodothyronine, T4), lossis propionic acid, yog ib qho tseem ceeb tshaj plaws cov tshuaj hormones zais los ntawm cov qog qog. T4 yog qhov muab los ntawm L-tyrosine nrog ntxiv ntawm 4 iodine molecules.

T4 nws tus kheej yog kev ua haujlwm tsis zoo. Nws tau qhib los ntawm selenium-dependent monodeiodinase enzyme. Cov enzyme no hloov T4 rau hauv daim ntawv ntawm triiodothyronine nrog kev ua haujlwm lom siab.

Yuav ua li cas cov thyroid hormones tsim tawm

Hauv qhov sib piv ntawm qib tag nrho cov tshuaj hormones, hauv qhov nyiaj tsim los ntawm cov qog qog, 4/5 feem yog T4, 1/5 feem yog triiodothyronine. Thyroxine yog ua ke nrog kev koom tes ntawm thyrotropin, tsim los ntawm cov ntaub so ntswg ntawm cov thyroid caj pas. Nws sib sau ua ke ntev vim qhov ua haujlwm qis.

Tag nrho tus naj npawb ntawm T4, uas yuav tsum tau tsim los ntawm cov thyroid caj pas, yog vim nws cov ntsiab lus hauv cov ntshav. Cov cai no pub dawb T4 rau cov poj niam los ntawm lub hnub nyoog tau muab rau hauv lub rooj nrog cov chav ntawm pmol / l.

Thaum siab ntau ntawm thyroxine, hlau tso tsawg dua ntawm nws. Nrog cov ntsiab lus qis ntawm T4, cov qog ua haujlwm hauv lub cev tso tawm nws ntau dua kom txog thaum tau txais qhov kev mloog zoo ib txwm, uas ua kom lub neej ntawm poj niam. Kev sib xyaw ntawm thyroxine yog vim lwm yam sab nraud. Yog li, nrog kev mob hypothermia ntev, tus poj niam cov khoom lag luam nce ntxiv.

Kev ua haujlwm ntawm T4 hauv poj niam lub cev

Thyroxine cuam tshuam rau cov nqaij ntawm lub cev ntawm qib cellular. Tsis muaj cov cell tshwj xeeb uas qhia txog qhov xav tau tshwj xeeb rau nws. Lub luag haujlwm tseem ceeb ntawm T4 yog txhawm rau txhim kho cov txheej txheem zom zaub mov.

T4 cuam tshuam:

• kev tswj ntawm lub cev kub;
• normalization ntawm cov thyroid ua haujlwm;
• tsim cov pob txha qauv;
• acceleration ntawm cov metabolism;
• kev loj hlob ntawm cov nqaij;
• txhim kho poj niam lub cev;
• kev loj hlob ntawm kev ua me nyuam;
• tus nqi ntawm kev ua me nyuam;
• nce hauv plawv dhia;
• thickening ntawm cov hnoos qeev hauv lub tsev menyuam;
• nce kev tsim dua tshiab ntawm cov leeg nqaij.

Cov txiaj ntsig no dhau los ua tau los ntawm kev ua kom muaj protein ntau. Tus nqi T4 dawb hauv cov poj niam los ntawm hnub nyoog tuaj yeem pom los ntawm lub rooj hauv pmol / l units.

Hom twg yog T4 hauv lub cev?

Lub cev muaj T4 hauv 2 hom:

• dawb, muaj kev lom zem heev;
• txuas, tsis siv.

Ntawm tag nrho cov ntsiab lus ntawm thyroxine, 99.9% yog T4 ntawm hom tsiaj, 0.1% yog pub dawb. Yog li ntawd, cov kws pab kuaj mob feem ntau txiav txim siab 2 yam: tag nrho cov concentration, ntsuas ntawm hom tsiaj pub dawb.

Kev txiav txim siab cov ntaub ntawv tshuaj xyuas hauv cov poj niam yog ua los ntawm tus kws endocrinologist, tus kws kho mob poj niam, suav nrog tus neeg mob lub hnub nyoog. Nws yog hnub nyoog uas kws kho mob txiav txim siab qhov qub ntawm T4. Hauv cov chaw soj nstuam, hluavtaws T4 tau tsim, uas tuaj yeem rov kho tau yooj yim thyroxine tsis txaus. Cov cai ntawm T4 pub dawb rau cov poj niam los ntawm hnub nyoog tau qhia hauv lub rooj, hauv pmol / l.

Poj niam hnub nyoog	Cov cai ntawm kev pub dawb T4 raws li poj niam lub hnub nyoog, hauv pmol / l
Ntau tshaj 20 xyoo	10, 5 – 21, 8
Ntau tshaj 30 xyoo	9, 0 – 22, 0
50-60 xyoo	7, 0 – 15, 4
60-70 xyoo	4, 0 – 13, 5
Tom qab 70 xyoo	4, 0 – 12, 4

Lub luag haujlwm ntawm tag nrho lub cev ntawm tus poj niam yog nyob ntawm qhov ua haujlwm raug ntawm cov thyroid caj pas, tus nqi ntawm cov tshuaj thyroxine. Los ntawm lub rooj koj tuaj yeem paub tus nqi dawb T4 hauv cov poj niam los ntawm hnub nyoog hauv pmol / l.

Ua kom T4 qhov tseem ceeb ntawm daim ntawv dawb txhais tau tias pom ntawm hyperthyroidism hauv tus poj niam, uas yog nrog los ntawm cov kab mob pathological ntau lawm ntawm cov thyroid hormones. Kev txo qis hauv kev sib xyaw ntawm T4 dawb txhais tau tias kev txhim kho hypothyroidism. Nws tau kuaj pom ntau zaus hauv cov poj niam tshaj 55. Hauv tus kab mob no, muaj qhov txo qis hauv cov nqaij cov thyroid, uas ua rau muaj kev txo qis ntau dua hauv kev sib xyaw ntawm T4.

Ob qho xwm txheej xav tau kev kho mob kho kom rov zoo li qub. Hauv qhov no, koj tsis tuaj yeem ua yam tsis muaj kev pab los ntawm tus kws endocrinologist. Kev kho nrog tshuaj hormonal tau sau tseg hauv kev saib xyuas ntawm kws kho mob.

Ua kom cov ntsiab lus thyroxine ntau ntxiv los ntawm kev sau tshuaj:

• Levothyroxine;
• Furosemide;
• Amiodarone;
• Anazole;
• Propranolol;
• Propylthiouracil.

Txo qhov siab T4 qhov tseem ceeb los ntawm kev sau tshuaj:

• Octreotide;
• Phenytoin;
• Tshuaj txiav yeeb;
• Carbamazepine;
• lithium media;
• thyreostatics;
• Clofibrate.

Cov tshuaj tsim nyog, tsim nyog nyob rau hauv ib rooj plaub tshwj xeeb, tau txiav txim los ntawm tus kws kho mob raws li poj niam lub hnub nyoog, nws lub cev hnyav, cov tshuaj thyroxine.